Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis
Main finding · Incident knee OAResult — go to the resultHazard ratio 1.29 95% CI 1.02–1.78Authors' conclusion
DM, bad glycemic management, and long-term DM are potential risk factors of symptomatic knee OA independent of age and body mass index.
Study context
- Population
- Community-based cohort of older adults without knee osteoarthritis (OA)median follow-up 5 years
- Participants
- 10,730 participants
- Exposure
- Diabetes mellitus (DM) vs no DM; poor vs good glycemic control; long-term vs short-term DM
- Outcome
- Incident symptomatic knee OA
Methodological detailscommunity-based, Cox regression stratified by DM status, spline model
- Community-based
- Cox regression stratified by DM status
- Spline model
Main finding
Incident knee OA · median follow-up 5 years
Hazard ratio
1.29
95% CI 1.02–1.78
Events by group
DM
108
events
Without DM
971
events
DMvs Without DM
HR 1.29 (95% CI 1.02–1.78)
As reported in the abstract
- Knee OA developed (total)
- 1,089
Observational data: associations, not effects.
Further findings
Knee OA with poor glycemic control (HbA1c ≥7%) in DM
- Poor glycemic control in DM, HR
- 1.41 (95% CI 1.05-2.09)
Knee OA with long-term DM (≥5 vs <5 years)
- Long-term DM ≥5 vs <5 years, HR
- 1.49 (95% CI 1.02-2.17)
HbA1c and fasting blood glucose levels (spline model)
- HbA1c >7.7% and 61 mmoles/mole and fasting blood glucose >186 mg/dl significantly associated with higher risk of incident knee OA
Original publication
Association of Diabetes Mellitus Status and Hyperglycemia With Symptomatic Knee Osteoarthritis. Arthritis Care Res (Hoboken). Published 17 October 2022. doi:10.
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