Association of depressive symptoms with incident fractures: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT)
Main finding · Hip fractures in womenResult — go to the resultAdjusted odds ratio 2.78 95% CI 1.30–5.92Authors' conclusion
Depressive symptoms in women may increase the risk of hip fractures.
Study context
- Population
- Japanese adults aged 40–74 years without past fractures at baseline, JPHC-NEXT, enrolled 2011–201630,552 men and 38,063 women analysed
- Exposure
- Depressive symptoms vs no depressive symptoms
- Outcome
- Self-reported vertebral, upper limb and/or hip fractures (excluding traffic or work accidents)
- Follow-up
- 5 years
Methodological details5-year longitudinal, logistic regression
- 5-year longitudinal
- Logistic regression
Main finding
Hip fractures in women
Adjusted odds ratio
2.78
95% CI 1.30–5.92
Depressive symptomsvs No depressive symptoms
aOR 2.78 (95% CI 1.30–5.92)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Fractures in men (any age group, any fracture type) · 5 years
- No association found in men for any age group or any type of fracture
Original publication
Association of depressive symptoms with incident fractures: the Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT). Osteoporos Int. Published 11 May 2024. doi:10.
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