Association between serum interleukin-17 levels and ectopic bone formation in of the posterior longitudinal ligament (OPLL) patients with diffuse idiopathic skeletal hyperostosis (DISH)
Authors' conclusion
The morphological characteristics of paravertebral bone formation in the entire spine, including the SI joint, are likely associated with serum IL-17 levels in OPLL.
Study context
- Population
- Patients with OPLL with or without DISH and age- and gender-matched controls103 OPLL patients
- Participants
- 53 / 50 / 53
- Comparison
- OPLL with DISH vs OPLL without DISH vs non-OPLL controls
- DISH (+)n = 53
- DISH (-)n = 50
- Controlsn = 53reference
- Outcome
- Serum IL-17 levels in relation to severity and morphology of heterotopic ossification in spinal ligaments including sacroiliac (SI) joints
Methodological detailsage- and gender-matched controls
- Age- and gender-matched controls
Main finding
As reported in the abstract
Serum IL-17 levels
- DISH (+) showed higher IL-17 levels than DISH (-), especially in female patients
- P = 0.003
Observational data: associations, not effects.
Further findings
Correlation of IL-17 with number of flat vertebral units
- Positive correlation, R2
- 0.199
- P
- P = 0.012
IL-17 in bridging osteophyte and bone fusion type
- Significantly higher in DISH (+) than DISH (-)
Original publication
Association between serum interleukin-17 levels and ectopic bone formation in OPLL patients with DISH. Rheumatology (Oxford). Published 27 October 2023. doi:10.
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