Association between periodontitis and temporomandibular joint disorders
An erratum to this article was published (Arthritis Res Ther, 21 Oct 2023 ↗)
Authors' conclusion
This research does not support a causal relationship between PD and TMD. PD does not appear to worsen TMD directly, and vice versa.
Study context
- Population
- Genome-wide association study (GWAS) data: Periodontitis (PD) from the Gene-Lifestyle Interaction in the Dental Endpoints (GLIDE) consortium; TMD from FinnGen and UK Biobank consortia
- Comparison
- Genetically predicted periodontitis vs TMD, and vice versa
- Outcome
- Causal association between PD and TMD (both directions)
Methodological detailsInverse variance weighted (IVW), weighted median, MR-Egger and MR-PRESSO methods, fixed-model meta-analysis of FinnGen and UK Biobank (UKB) results
- IVW, weighted median, MR-Egger and MR-PRESSO methods
- Fixed-model meta-analysis of FinnGen and UKB results
Pooled result
As reported in the abstract
Causal effect between PD and TMD
- PD did not appear to causally affect TMD
- Reverse Mendelian randomization (MR): no significant causal effect of TMD on PD
Further pooled results
- Other MR methods similar to IVW
- Sensitivity analyses: no potential pleiotropy
- Meta-analysis consistent with the main results
Original publication
Association between periodontitis and temporomandibular joint disorders. Arthritis Res Ther. Published 8 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →