Spondyloarthritis & psoriatic arthritis
Association Between Metabolic Syndrome and Radiographic Changes in Psoriatic Arthritis: A Cohort Study
Authors' conclusion
MetS is associated with degenerative and metabolic changes in the spine and entheses but not with radiographic damage in PsA.
Study context
- Population
- Patients with psoriatic arthritis (PsA) followed at a prospective observational cohort, 1978–2024836 with metabolic syndrome (MetS) over follow-up
- Participants
- 1,422 patients
- Exposure
- MetS vs no MetS
- Outcome
- Radiographic features (peripheral and axial) independently associated with MetS
Methodological detailsgeneralized estimating equations (GEE) analysis, adjusted for age, sex, PsA disease duration, calendar decade and targeted DMARD use
- Generalized estimating equations (GEE) analysis
- Adjusted for age, sex, PsA disease duration, calendar decade and targeted DMARD use
Main finding
As reported in the abstract
Radiographic features associated with MetS (GEE)
- MetS not significantly associated with axial disease (syndesmophytes or sacroiliitis)
- MetS not significantly associated with radiographic damage to peripheral joints (radiographic damaged joint count)
- MetS significantly associated with calcaneal spurs, diffuse idiopathic skeletal hyperostosis and degenerative disc disease
- Adjusted for age, sex, PsA disease duration, calendar decade and targeted DMARD use
Observational data: associations, not effects.
Further findings
Prevalence of MetS · baseline (clinic entry) and median follow-up 10.59 (IQR 4.52-18.28) years
- MetS at baseline
- 400 (28.1%)
- Record of MetS (harmonized definition) over follow-up
- 836 (58.79%)
Original publication
Association Between Metabolic Syndrome and Radiographic Changes in Psoriatic Arthritis: A Cohort Study. Arthritis Care Res (Hoboken). Published 22 March 2025. doi:10.
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