Association between the frequency of achieving recommended daily step counts and a decline in quantitative ultrasound measurements in premenopausal and postmenopausal women: a 4-year prospective study of the Tohoku Medical Megabank Community-Based Cohort study
Main finding · Incidence of a decline in QUS measurements (QUS T-score ≤−2.5 or self-reported diagnosis of osteoporosis), premenopausal womenResult — go to the resultAdjusted relative risk 0.478 95% CI 0.271–0.843Authors' conclusion
The findings suggest that the association appeared to differ by menopausal status, achieving 7000 steps/day on ≥3 days/week was associated with a significantly reduced risk of a decline in QUS measurements in premenopausal women. However, for postmenopausal women, walking alone may be an insufficient strategy.
Study context
- Population
- Pre- and postmenopausal women of the Tohoku Medical Megabank Community-Based Cohort; baseline surveys 2013–2016 and follow-up surveys 2017–2021women, mean follow-up: 42.5 months · premenopausal 1,013 · postmenopausal 2,516
- Participants
- 3,529 participants
- Exposure
- Frequency of achieving 7000 steps/day vs Inactive group as the reference
- Outcome
- Incidence of a decline in QUS measurements (QUS T-score ≤−2.5 or self-reported diagnosis of osteoporosis), premenopausal women
- Follow-up
- During
Methodological detailsmodified Poisson regression models
- Modified Poisson regression models
Main finding
As reported in the abstract
Adjusted relative risk
0.478
95% CI 0.271–0.843
Activevs Inactive
Adjusted RR 0.478 (95% CI 0.271–0.843)
- Premenopausal women with the outcome
- 70
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| Incidence of a decline in QUS measurements, postmenopausal women · During follow-upActivevs Inactive | 0.937 (0.807–1.088) | |
| 0.512Adjusted relative risk (log scale) |
- Incidence of a decline in quantitative ultrasound (QUS) measurements, postmenopausal women — Postmenopausal women with the outcome
- 662
Incidence of a decline in QUS measurements, Low active (1-2 days/week)
- No significant association in either premenopausal or postmenopausal women
Original publication
Association between the frequency of achieving recommended daily step counts and a decline in quantitative ultrasound measurements in premenopausal and postmenopausal women: a 4-year prospective study of the Tohoku Medical Megabank Community-Based Cohort study. Osteoporos Int. Published 23 October 2026. doi:10.
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