Identifying Younger Postmenopausal Women With Osteoporosis Using USPSTF-Recommended Osteoporosis Risk Assessment Tools
Authors' conclusion
In this cross-sectional study, 3 guideline-recommended osteoporosis risk assessment tools had fair to moderate discrimination in identifying osteoporosis defined by lowest BMD at any 1 of 3 skeletal sites.
Study context
- Population
- Healthy postmenopausal women aged 50 to 64 years with bone mineral density (BMD) measurements, WHI Bone Density Substudy, 3 clinical centers (Tucson and Phoenix, Arizona; Pittsburgh, Pennsylvania; Birmingham, Alabama), data collected 1993–1998mean age 57.7 years
- Participants
- 6,067 women
- Exposure
- Osteoporosis Risk Assessment Instrument (ORAI) and Osteoporosis Index of Risk (OSIRIS) vs OST for identifying osteoporotic BMD
- Outcome
- Osteoporosis defined by BMD T score of −2.5 or lower at 1 or more of femoral neck, total hip and/or lumbar spine; tools evaluated by AUC
Methodological detailsmulticentre (3 clinical centers), secondary use of Women's Health Initiative Bone Density Substudy data, Data collected October 1993 to December 1998; analysed September 23, 2023, to April 10, 2024
- Multicentre (3 clinical centers)
- Secondary use of Women's Health Initiative Bone Density Substudy data
- Data collected October 1993 to December 1998; analysed September 23, 2023, to April 10, 2024
Main finding
As reported in the abstract
AUC for identifying osteoporosis at any site
| Group | AUC |
|---|---|
| OSIRIS | 0.633 (95% CI, 0.633-0.634) |
| ORAI | 0.663 (95% CI, 0.663-0.664) |
| OST | 0.654 (95% CI, 0.654-0.655) |
AUC
OSIRIS0.633 (95% CI, 0.633-0.634)
ORAI0.663 (95% CI, 0.663-0.664)
OST0.654 (95% CI, 0.654-0.655)
Observational data: associations, not effects.
Further findings
Prevalence of osteoporosis at any 1 of 3 anatomical sites
- Prevalence of osteoporosis (n = 857)
- 14.1%
Original publication
Identifying Younger Postmenopausal Women With Osteoporosis Using USPSTF-Recommended Osteoporosis Risk Assessment Tools. JAMA Netw Open. Published 3 March 2025. doi:10.
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