The association between ethnicity, socioeconomic position and outcomes following initiation of TNF inhibitors in juvenile idiopathic arthritis: results from the UK juvenile idiopathic arthritis (JIA) Biologics Register
Authors' conclusion
Outcomes following TNFi initiation are similar between ethnic and socioeconomic groups.
Study context
- Population
- Patients with non-systemic JIA in the UK JIA Biologic Register starting their first TNF-inhibitors (TNFi) biologic67% female
- Participants
- 1,641 patients
- Exposure
- Ethnic groups and socioeconomic groups after first TNFi initiation
- Outcome
- Change in disease activity (JADAS-71) between start of TNFi and 6 months
- Follow-up
- 6 months
Methodological detailsUK JIA Biologics Register, registry-based, multivariable linear regression, Kaplan-Meier estimates, Cox proportional hazards models
- UK JIA Biologics Register
- Registry-based
- Multivariable linear regression
- Kaplan-Meier estimates
- Cox proportional hazards models
Main finding
As reported in the abstract
Change in JADAS-71 by ethnic and socioeconomic group
- JADAS-71 improved for all ethnic and socioeconomic groups, with no difference in improvement by group
Observational data: associations, not effects.
Further findings
Remaining on TNFi (treatment persistence) · 12 months
- Proportion remaining on TNFi, all patients
- 67%
- Proportion remaining on TNFi and likelihood of stopping similar between all ethnic and socioeconomic groups
Original publication
The association between ethnicity, socioeconomic position and outcomes following initiation of TNF inhibitors in juvenile idiopathic arthritis: results from the UK JIA Biologics Register. Rheumatology (Oxford). Published 19 June 2026. doi:10.
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