Association between combined exposure to ambient air pollutants, genetic risk, and incident gout risk: A prospective cohort study in the UK Biobank
Authors' conclusion
Long-term exposure to air pollutants, particularly among the elderly population, is associated with an increased risk of gout.
Study context
- Population
- Initially gout-free participants enrolled in the UK Biobank7,927 incident gout cases
- Participants
- 458,884 participants
- Exposure
- Per IQR increase in long-term exposure to air pollutants (NO2, NOx, PM10, PMcoarse, PM2.5) and air pollution score
- Outcome
- Incident gout
- Follow-up
- Median 12.0 years
Methodological detailsUK Biobank, land use regression model, weighted air pollution score, Cox proportional hazards model, interaction and stratification analyses, mediation analyses
- UK Biobank
- Land use regression model
- Weighted air pollution score
- Cox proportional hazards model
- Interaction and stratification analyses
- Mediation analyses
Main finding
As reported in the abstract
Incident gout per IQR increase in pollutant
Hazard ratio (95 % CI)P value
NO2 (per IQR increase)
1.05(1.02–1.08)
P = 0.003NOx (per IQR increase)
1.04(1.01–1.06)
P = 0.003PM2.5 (per IQR increase)
1.03(1.00–1.06)
P = 0.030Per IQR increase, as printed
Observational data: associations, not effects.
Further findings
Air pollution score and gout risk, stratified by age (subgroup)
| HR (95 % CI) | P value | ||
|---|---|---|---|
| Air pollution score, age ≥60 years | 1.05 (1.02–1.09) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
| Outcome | P value |
|---|---|
| Air pollution score and gout risk, stratified by age (subgroup)Air pollution score, age <60 years · not significant | P = 0.793 |
- Air pollution score and gout risk, stratified by age (subgroup) — Interaction with age
- p-interaction=0.009
Mediation by serum biomarkers (proportion mediated)
%
- SUA
- 15.87
- VITD
- 5.04
- LDLD
- 3.34
- GGT
- 1.90
- AST
- 1.56
Original publication
Association between combined exposure to ambient air pollutants, genetic risk, and incident gout risk: A prospective cohort study in the UK Biobank. Semin Arthritis Rheum. Published 30 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →