Lupus & antiphospholipid syndrome
Association between cognitive impairment and olfactory deficits in systemic lupus erythematosus without major neuropsychiatric syndromes
Authors' conclusion
This study indicates that significantly cognitive and olfactory functions are impaired in SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients without major neuropsychiatric syndromes and healthy controls
- Participants
- 55 vs 50
- Exposure
- SLE vs healthy controls
- SLEn = 55
- Healthy controlsn = 50reference
- Outcome
- Cognitive function (RBANS: immediate memory, visuospatial/constructional, language, attention, delayed memory) and its relationship with olfactory function (threshold, identification, memory)
Main finding
As reported in the abstract
RBANS scores
- SLE had significantly lower total Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), immediate memory (IMME), Vis/Con, attention (ATT) and delayed memory (DEME) index scores than healthy controls
- p < 0.01 for all and p = 0.027 for attention
- Olfactory memory and total scores correlated with DEME
- r = 0.393, p = 0.021
- Olfactory memory and total scores correlated with total RBANS scores
- r = 0.429, p = 0.011
Observational data: associations, not effects.
Further findings
Anosmia and hyposmia
χ2 10.533 · P = 0.015
Anosmia
Hyposmia
Cognitive function (total RBANS, IMME, Vis/Con, ATT and DEME index scores)
- SLE patients had significantly lower total RBANS, IMME, Vis/Con, ATT and DEME index scores than healthy controls (p < 0.01 for all and p = 0.027 for attention)
Olfactory scores
- All olfactory scores significantly decreased in SLE patients vs controls (p = 0.001)
Correlation of olfactory memory and total scores with DEME and total RBANS scores
- Correlation with DEME
- r = 0.393, p = 0.021
- Correlation with total scores
- r = 0.429, p = 0.011
Original publication
Association between cognitive impairment and olfactory deficits in systemic lupus erythematosus without major neuropsychiatric syndromes. Lupus. Published 12 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →