Association between clinical use of nifedipine and the risk of osteoporosis: a nationwide retrospective cohort study
Main finding · OsteoporosisResult — go to the resultAdjusted hazard ratio 0.44 95% CI 0.37–0.53Authors' conclusion
This population-based cohort study demonstrated that nifedipine may have potential protective effect on osteoporosis compared with other CCBs.
Study context
- Population
- Patients receiving Calcium Channel Blockers (CCBs), National Health Insurance Research Database of Taiwan, 2000 to 2013
- Participants
- 1,225 vs 4,900
- Exposure
- Nifedipine vs other CCBs
- Nifedipinen = 1,225
- Other CCBsn = 4,900reference
- Outcome
- Diagnosis of osteoporosis
Methodological detailsnationwide, population-based
- Nationwide
- Population-based
Main finding
Osteoporosis
Adjusted hazard ratio
0.44
95% CI 0.37–0.53
Nifedipinevs Other CCBs
aHR 0.44 (95% CI 0.37–0.53)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Osteoporosis by sex and age group (subgroups)
- Inverse association evident in both sexes and various age groups
Original publication
Association between clinical use of nifedipine and the risk of osteoporosis: a nationwide retrospective cohort study. Osteoporos Int. Published 20 April 2023. doi:10.
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