Assessment of myositis specific antibodies in primary chronic arthritis: single centre prospective study
Authors' conclusion
MSAs positivity may be observed in one third of patients with primary isolated arthritis. About half of these cases displayed full or weak positivity for MSAs, whereas the remaining half displayed borderline results.
Study context
- Population
- Patients with established rheumatoid arthritis (RA), psoriatic arthritis (PsA) or undifferentiated polyarthritis (UPA) followed in an Early Arthritis Clinic, January 2021 to December 202493 females, 65%
- Participants
- 143 patients
- Outcome
- Prevalence of myositis specific antibodies (MSAs) (line-blot) in baseline serum
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MSA line-blot result · baseline
Positive
10
7%
Weak-positive
12
8%
Borderline
26
18%
Negative
95
67%
Observational data: associations, not effects.
Further findings
MSA specificities
- Positive: anti-cN1A
- 3
- Positive: anti-ARS
- 4
- Positive: anti-MDA
- 4
- Weak-positive: anti-ARS
- 4
- Weak-positive: anti-PM-Scl75
- 3
- Borderline: anti-ARS and aMDA5
- 12, 46%
Variables associated with MSA positivity
- No variables were associated with MSA positivity
Original publication
Assessment of myositis specific antibodies in primary chronic arthritis: single centre prospective study. Clin Exp Rheumatol. Published 18 May 2025. doi:10.
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