Autoinflammatory & rare systemic diseases
Assessing IgG4-related autoimmune pancreatitis with contrast-enhanced ultrasonography based on time-intensity curve: a single-centre prospective study
Authors' conclusion
CEUS based on TIC holds great potential for assessing response to treatment in patients with IgG4 AIP.
Study context
- Population
- Patients with active IgG4-related autoimmune pancreatitis, enrolled June 2021 to November 2022
- Participants
- 73 patients
- Exposure
- Contrast-enhanced ultrasound (CEUS) time-intensity curves (TIC) parameters after treatment vs baseline
- Outcome
- Changes in CEUS TIC parameters after treatment vs baseline
- Follow-up
- follow-up
Methodological detailssingle-centre, before-and-after treatment
- Single-centre
- Before-and-after treatment
Main finding
As reported in the abstract
- Significant increase in peak intensity (PI) in pancreatic head, body and tail after treatment
- p<0.001
- Significant rise in AUC in pancreatic tail after treatment
- p=0.029
Observational data: associations, not effects.
Further findings
| Outcome | Baseline | P value |
|---|---|---|
| Maximum diameter of pancreatic lesion · follow-upAfter treatment vs Baseline | 4.3 ± 2.0 cm | P = 0.01 |
- Maximum diameter of pancreatic lesion: After treatment 1.7 ± 1.6 cm
PI in diffuse IgG4-AIP (subgroup, 12 patients) · after treatment
- Significant increase of PI following treatment
PI in focal area, focal lesions (subgroup, 12 patients) · after treatment
- Significant increase in PI following treatment
Original publication
Assessing IgG4-related autoimmune pancreatitis with contrast-enhanced ultrasonography based on time-intensity curve: a single-centre prospective study. Clin Exp Rheumatol. Published 31 May 2024. doi:10.
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