Lupus & antiphospholipid syndrome
Argonaute, Vault, and Ribosomal Proteins Targeted by Autoantibodies in Systemic Lupus Erythematosus
Authors' conclusion
We discovered new autoantigens existing in cytosolic macromolecular protein assemblies containing RNA (except the proteasome) in cells.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), healthy controls and patients with other rheumatic diseases
- Comparison
- Serum from patients with SLE vs healthy controls and other rheumatic diseases
- SLE (screen)n = 12
- Healthy controlsn = 6reference
- Cohort 1n = 49
- Cohort 2n = 46
- Outcome
- IgG and IgA binding to human proteome arrays (autoantigen discovery) and clinical associations
Methodological detailsunbiased human proteome array screen (> 21,000 proteins), ELISA validation in 2 cohorts
- Unbiased human proteome array screen (> 21,000 proteins)
- ELISA validation in 2 cohorts
Main finding
As reported in the abstract
Autoantigens identified
Positive for the novel antigens (95th percentile of healthy donor reactivity)
5-43%
Further findings
Clinical associations
- Anti-AGO1 autoantibodies significantly more prevalent in patients with oral ulcers
Other rheumatic diseases
- IgG autoantibodies against AGO proteins also seen in other rheumatic diseases
Original publication
Argonaute, Vault, and Ribosomal Proteins Targeted by Autoantibodies in Systemic Lupus Erythematosus. J Rheumatol. Published 1 May 2023. doi:10.
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