Autoinflammatory & rare systemic diseases
Adult-onset Still's disease (AOSD) endotypes based on immune cell profiles: patient stratification with hierarchical clustering analysis
Authors' conclusion
Hierarchical cluster analysis of peripheral immune cells classified AOSD into three disease-related endotypes. Group 3 showed higher systemic score and poorer treatment responses.
Study context
- Population
- Treatment-naïve patients with AOSD and healthy controls95 AOSD, 66 controls
- Exposure
- AOSD endotypes defined by circulating immune cells; AOSD vs healthy controls
- Healthy controlsn = 66reference
- Outcome
- Immune cell profiles and endotypes
Methodological detailsunbiased hierarchical cluster analysis, treatment-naïve patients
- Unbiased hierarchical cluster analysis
- Treatment-naïve patients
Main finding
As reported in the abstract
- Neutrophils and CD8+ T cells higher; monocytes, NK and CD4+ T cells lower in AOSD vs controls
- all P < 0.005
Observational data: associations, not effects.
Further findings
CD4/CD8 ratio correlation with systemic score (negative) and treatment response (positive)
- Negative correlation with systemic score
- P = 0.001
- Positive correlation with treatment response
- P = 0.0091
Total disease flares · 24.6 (15.2) months of follow-up
- Highest in CD8-dominant
- P < 0.0001
Original publication
AOSD endotypes based on immune cell profiles: patient stratification with hierarchical clustering analysis. Rheumatology (Oxford). Published 16 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →