Lupus & antiphospholipid syndrome
Antiphospholipid antibody positivity in early systemic lupus erythematosus is associated with subsequent vascular events
Authors' conclusion
Double/triple-positivity for IgG anti-CL, anti-β2GPI and anti-DI in early SLE identifies a population at higher risk of subsequent VE.
Study context
- Population
- Patients with SLE with serum tested early in disease for IgG anti-cardiolipin (anti-CL), anti-β2GPI and anti-DI by ELISA; patients with vascular events (VE) before SLE diagnosis excluded501 tested
- Participants
- 400 patients
- Exposure
- aPL-positive vs aPL-negative early in SLE; double/triple-positive vs single-positive vs aPL-negative
- Double/triple-positiven = 27
- Single-positiven = 127
- Outcome
- Subsequent vascular events (VE)
Methodological detailsKaplan-Meier survival analysis
- Kaplan-Meier survival analysis
Main finding
As reported in the abstract
VE
VE in patients
91 VE in 77 patients, 42 aPL-positive in early disease
Observational data: associations, not effects.
Further findings
aPL positivity (one or more)
- Positive for one or more aPL
- 154 (38.5%)
Omission of IgG anti-DI assay
- Double/triple-positive patients missed (of whom six had VE)
- 14
Original publication
Antiphospholipid antibody positivity in early systemic lupus erythematosus is associated with subsequent vascular events. Rheumatology (Oxford). Published 13 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →