Antihistamine use and osteoarthritis or joint pain
Main finding · Prevalent OA at EpiHealth (cross-sectional)Result — go to the resultRelative risk 1.13 95% CI 1.06–1.20Authors' conclusion
In a large population-based observational cohort, use of antihistamines was neither associated with less joint pain/osteoarthritis nor lower risk of future osteoarthritis.
Study context
- Population
- EpiHealth cohort, persons aged 45 to 75 from Malmö/Uppsala, Sweden; study visit 2010–2016
- Participants
- 25,003 participants
- Exposure
- Antihistamine use vs no use
- Outcome
- Prevalent OA (any location), current pain in knees/hips/hands-wrists, and future incident OA diagnosis
Methodological detailspopulation-based, cross-sectional and longitudinal analyses, negative control (penicillin), adjusted for age, sex, BMI, allergy and use of healthcare
- Population-based
- Cross-sectional and longitudinal analyses
- Negative control (penicillin)
- Adjusted for age, sex, BMI, allergy and use of healthcare
Main finding
Prevalent OA at EpiHealth (cross-sectional)
Relative risk
1.13
95% CI 1.06–1.20
Antihistaminesvs No antihistamines
RR 1.13 (95% CI 1.06–1.20)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Joint pain at EpiHealth (cross-sectional)Adjusted | RR 1.02 (CI 0.99–1.05) | |
| Future incident OA diagnosis (longitudinal)Adjusted | HR 1.15 (CI 1.03–1.28) | |
| Negative control: penicillin use and future incident OA diagnosisPenicillinvs No penicillin | HR 1.16 (CI 1.07–1.25) | |
| 0.512Ratio (log scale) |
Original publication
Antihistamine use and osteoarthritis or joint pain. Osteoarthritis Cartilage. Published 12 September 2024. doi:10.
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