Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis
Authors' conclusion
Anti-PAD4 and anti-PAD3 antibodies identify RA patients with higher radiographic injury and bone erosions. In our cohort, ILD is associated with lower radiographic and erosive damage, as well as low levels of anti-PAD4 antibodies.
Study context
- Population
- Patients fulfilling the 2010 ACR/EULAR RA classification criteria, with articular involvement and interstitial lung disease (ILD) assessed
- Participants
- 71 patients
- Outcome
- Associations of anti-PAD4, anti-PAD3 and ACPA with joint damage and RA-ILD
Main finding
As reported in the abstract
- Anti-PAD4 associated with radiographic injury
- P = 0.027
- Anti-PAD4 associated with erosions
- P = 0.02
- ACPA levels associated with erosive disease
- P = 0.014
- Anti-PAD3/4 double-positive: more joint erosions than anti-PAD4 only
- P = 0.014
- Anti-PAD3/4 double-positive: more joint erosions than negative for both
- P = 0.037
- RA-ILD prevalence
- 15.5%, 11/71 patients
- RA-ILD associated with older age
- P < 0.001
- RA-ILD associated with shorter disease duration
- P = 0.045
- RA-ILD associated with less erosive disease
- P = 0.0063
- Anti-PAD4 negatively associated with RA-ILD
- P = 0.043
Observational data: associations, not effects.
Original publication
Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis. Rheumatology (Oxford). Published 28 November 2022. doi:10.
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