Lupus & antiphospholipid syndrome
Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients
Authors' conclusion
In two cohorts of different ethnical origins, autoantibodies targeting chromatin correlate stronger with IFN-induced inflammatory biomarkers than anti-dsDNA or other ANA sub-specificities.
Study context
- Population
- Sudanese and Swedish SLE patients and matched controls
- Exposure
- Associations of ANA sub-specificities (anti-histone, anti-nucleosome, anti-dsDNA and others) with inflammatory biomarkers incl. IFN-regulated chemokines
- Sudanese SLEn = 93
- Swedish SLEn = 480
- Controlsn = 104 + 192reference
- Outcome
- Associations of ANA sub-specificities with 72 plasma inflammatory biomarkers incl. IFN-regulated chemokines
Methodological detailstwo cohorts (Sudanese and Swedish), matched controls, bead-based multiplex immunoassay, Proximity Extension Assay or ELISA
- Two cohorts (Sudanese and Swedish)
- Matched controls
- Bead-based multiplex immunoassay
- Proximity Extension Assay or ELISA
Main finding
As reported in the abstract
Associations of ANA sub-specificities with biomarkers
- Sudanese: investigated antibodies significantly associated with 9/72 biomarkers
- Sudanese: anti-histone showed strongest positive correlations with MCP-3, S100A12 and IFN I-inducible MCP-1 and CXCL10
- Sudanese: anti-dsDNA associated with CXCL10 and S100A12, but associations lost significance in multivariate analyses, unlike anti-histone
- Swedish: MCP-1, CXCL10 and SA100A12 more strongly associated with anti-histone and anti-nucleosome than with anti-dsDNA and other ANA sub-specificities; anti-histone/nucleosome retained strongest associations in multiple regression
- Swedish: excluding anti-histone or anti-nucleosome positive patients, MCP-1/CXCL10 associations with anti-dsDNA were lost; excluding anti-dsDNA positive patients, associations with anti-histone and anti-nucleosome remained significant
- Anti-nucleosome measured only in Swedish patients
Observational data: associations, not effects.
Original publication
Anti-histone and anti-nucleosome rather than anti-dsDNA antibodies associate with IFN-induced biomarkers in Sudanese and Swedish SLE patients. Rheumatology (Oxford). Published 9 March 2024. doi:10.
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