Altered dynamic functional network connectivity in rheumatoid arthritis associated with peripheral inflammation and neuropsychiatric disorders
Authors' conclusion
Our findings demonstrated that abnormal DFC patterns in sensory processing networks in patients with RA were closely associated with peripheral inflammation and neuropsychiatric symptoms.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and healthy controls
- Participants
- 30 vs 30
- Exposure
- RA vs healthy controls
- RAn = 30
- Healthy controls (HCs)n = 30reference
- Outcome
- Dynamic functional connectivity (dynamic functional connective (DFC)) alterations and their correlation with neuropsychiatric symptoms and peripheral inflammation
Methodological detailsresting-state functional MRI, spatial independent component analysis, sliding window method
- Resting-state functional MRI
- Spatial independent component analysis
- Sliding window method
Main finding
As reported in the abstract
DFC alterations, RA vs HC
- Three dynamic functional states identified
- RA showed reduced FC variabilities between sensorimotor network (SMN) and insula, and SMN and orbitofrontal cortex (sensory processing network) vs HC
- These FC variabilities correlated with Montreal Cognitive Assessment (MoCA), HAD, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in RA
Observational data: associations, not effects.
Further findings
Inflammation markers vs neuropsychiatric scores in RA
- CRP and ESR negatively correlated with MoCA and positively with HAD
Diagnostic efficacy (ROC)
- MoCA, HAD and FC variabilities of the sensory processing network distinguished RA from HC and identified RA with high ESR
Original publication
Altered dynamic functional network connectivity in rheumatoid arthritis associated with peripheral inflammation and neuropsychiatric disorders. RMD Open. Published 29 February 2024. doi:10.
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