Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment
Authors' conclusion
Alterations in the lipidome of HUA and Gout patients show a significant impact on lipid metabolism. The most significant glycerophospholipid dysregulation was found in HUA ≤ 40 and Gout ≤ 40 patients, together with a correction of this imbalance with ULT.
Study context
- Population
- Patients with asymptomatic hyperuricemia (HUA), gout patients and normouricemic healthy controls; plasma lipidome (608 lipids)94 HUA, 196 gout, 53 healthy controls (HC)
- Exposure
- Asymptomatic HUA and gout vs normouricemic healthy controls
- HCn = 53reference
- Outcome
- Differences in plasma lipidome
Methodological detailscomprehensive targeted lipidomic analysis, univariate and multivariate statistics
- Comprehensive targeted lipidomic analysis
- Univariate and multivariate statistics
Main finding
As reported in the abstract
Plasma lipidome
Multivariate statistics differentiated HUA ≤ 40 and Gout ≤ 40 from HC, overall accuracy
> 95%
Observational data: associations, not effects.
Original publication
Alterations in lipidome profiles distinguish early-onset hyperuricemia, gout, and the effect of urate-lowering treatment. Arthritis Res Ther. Published 2 December 2023. doi:10.
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