Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study
Authors' conclusion
In actively treated patients with gout, anthropometric measures were largely unchanged over 2 years and lipid levels were reduced. High WC and lipid levels predicted unfavourable gout outcomes after 2 years.
Study context
- Population
- Patients with a recent gout flare and elevated serum urate (sUA) receiving gout education and treat-to-target ULT over 1 year (NOR-Gout)95% male
- Participants
- 211 patients
- Outcome
- Association of baseline anthropometric measures and lipid levels with flares and sUA target achievement
- Follow-up
- Year 2
Methodological detailslongitudinal, treat-to-target
- Longitudinal
- Treat-to-target
Main finding
As reported in the abstract
Higher baseline waist circumference (WC) decreased chance of sUA target achievement, OR per cm
0.96 (0.93 to 0.99) (95% CI)
High HDL cholesterol increased chance of sUA target achievement, OR per mmol/L
5.1 (1.2 to 22.1) (95% CI)
High low-density lipoprotein cholesterol (LDL-C) predicted gout flare during year 2, OR per mmol/L
1.8 (1.2 to 2.6) (95% CI)
Observational data: associations, not effects.
Further findings
Change in anthropometric measures and lipid levels over 2 years
- Anthropometric measures largely unchanged over 2 years
- Cholesterol and LDL-C reduced at year 1
- Anthropometric measures associated with presence of tophi
Original publication
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