Systemic sclerosis & Raynaud's
Accelerated Type VII collagen turnover in systemic sclerosis patients, reflected by serological neo-epitope fragment biomarkers
Authors' conclusion
In conclusion, PRO-C7 and C7M, reflecting type VII collagen turnover, show promise as new serological biomarkers for SSc.
Study context
- Population
- Patients with systemic sclerosis (SSc) and healthy controls
- Comparison
- SSc patients vs healthy controls
- Outcome
- Serum type VII collagen formation (PRO-C7) and degradation (C7M) biomarkers and their association with other ECM biomarkers and clinical manifestations
Methodological detailsautomated immunoassay development (PRO-C7), Bonferroni correction
- Automated immunoassay development (PRO-C7)
- Bonferroni correction
Main finding
As reported in the abstract
Type VII and VI collagen turnover biomarkers, SSc vs controls
- Significantly elevated levels of type VII and VI collagen turnover biomarkers in SSc patients and controls
Further findings
Association of biomarkers with modified Rodnan skin score (mRSS) (linear regression)
- PRO-C3 vs mRSS, R2
- 0.156, p = 0.0004
- PRO-C6 vs mRSS, R2
- 0.222, p < 0.0001
- PRO-C7 and C7M not significantly correlated with mRSS
Correlation of PRO-C7 with CRP and ESR (Spearman)
- PRO-C7 vs CRP, ρ
- 0.39, p = 0.0006
- PRO-C7 vs ESR, ρ
- 0.24 p = 0.045
Correlation of C7M with CRP and ESR (Spearman)
- C7M vs CRP, ρ
- 0.31, p = 0.0076
- C7M vs ESR, ρ
- 0.28, p = 0.014
Correlation with other collagen turnover biomarkers
- C7M correlated significantly with type III, IV and VI collagen formation and degradation biomarkers
- PRO-C7 correlated significantly only with PRO-C6 and C6M
Associations with clinical manifestations
- C7M higher in SSc patients with renal dysfunction
- Elevated PRO-C7 associated with anti-dsDNA
- Lower PRO-C7 linked to capillary abnormalities
Original publication
Accelerated Type VII collagen turnover in systemic sclerosis patients, reflected by serological neo-epitope fragment biomarkers. Arthritis Res Ther. Published 19 March 2025. doi:10.
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