A treatment algorithm for familial Mediterranean fever patients with menstruation-associated attacks
Authors' conclusion
This is the largest cohort of adolescent FMF patients with menstruation-associated attacks. Severe FMF may cause a tendency to this association.
Study context
- Population
- Female FMF patients who had menarche, Pediatric Rheumatology Unit, January–December 2022
- Participants
- 151 patients
- Exposure
- Menstruation-associated FMF attacks vs attacks not associated with menstruation
- Menstruation-associated attacksn = 35
- Outcome
- Menstruation-associated attacks (prevalence)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Menstruation-associated attacks
23.2%
35
Observational data: associations, not effects.
Further findings
Age at symptom onset
P = 0.004
Age at diagnosis
P = 0.01
Dysmenorrhea
P < 0.001
| Outcome | Menstruation-associated attacks | Attacks not associated with menstruation | Estimate | P value |
|---|---|---|---|---|
| Fever during attacks: menstruation-associated vs not associated, in patients with menstruation-associated attacks | 65.7% vs 88.6% | P = 0.01 | ||
| Arthritis during attacks: menstruation-associated vs not associated, in patients with menstruation-associated attacks | 2.9% vs 20% | P = 0.04 | ||
| Pre-menarche attack frequency | 4 | 2 | P < 0.001 for both | |
| Post-menarche attack frequency | 10 | 0 | P < 0.001 for both |
On-demand therapies for menstruation-associated attacks
- On-demand therapies were beneficial in controlling menstruation-associated attacks
Original publication
A treatment algorithm for familial Mediterranean fever patients with menstruation-associated attacks. Rheumatology (Oxford). Published 6 May 2024. doi:10.
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