Differentiating familial Mediterranean fever attacks from acute appendicitis in children: which laboratory parameters are useful?
Authors' conclusion
In differentiating FMF attacks from AA in children, physical examination and imaging can be supported by blood count-based parameters.
Study context
- Population
- Patients aged 0–18 years presenting with familial Mediterranean fever (FMF) attacks or suspected acute appendicitis (AA), Ankara Bilkent City Hospital Children's Hospital, 2019–2024
- Participants
- 600 patients
- Comparison
- FMF attacks vs acute appendicitis
- FMFn = 200
- AAn = 400
- Outcome
- Diagnostic value of inflammatory markers and DNI in differentiating FMF attacks from AA
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Laboratory markers, FMF vs AA
- WBC, absolute neutrophil count (ANC), neutrophil-to-lymphocyte ratio (NLR) and delta neutrophil index (DNI) significantly higher in AA
- p < 0.001
- Absolute lymphocyte count (ALC) and C-reactive protein (CRP) markedly elevated in FMF
- p < 0.001
- Multivariate logistic regression: increases in DNI and ANC, and decreases in CRP and PLT, significant predictors of AA
- p < 0.001
Original publication
Differentiating familial Mediterranean fever attacks from acute appendicitis in children: which laboratory parameters are useful? Scand J Rheumatol. Published 11 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →