Spondyloarthritis & psoriatic arthritis
A systematic review and meta-analysis of questionnaires to screen for pain sensitisation and neuropathic like pain in inflammatory arthritis
Authors' conclusion
Pain sensitivity and neuropathic like pain contribute to pain perception in up to 42% of patients with IA.
Study context
- Population
- Adult patients with inflammatory arthritis (IA)
- Participants
- 13,035 patients63 studies
- Comparison
- painDETECT vs DN4 vs LANSS vs CSI
- Outcome
- Prevalence of pain sensitivity/neuropathic like pain in IA, as defined by questionnaires
Methodological detailsmeta-regression, risk of bias assessed with National Institute of Health Quality Assessment Tool
- Meta-regression
- Risk of bias assessed with National Institute of Health Quality Assessment Tool
Pooled result
As reported in the abstract
Prevalence of pain sensitivity/neuropathic like pain in IA
Further pooled results
| Outcome | P value |
|---|---|
| Prevalence by IA type on meta-regression (painDETECT)RA vs SpA · RA significantly lower | P = 0.01 |
| Prevalence by IA type on meta-regression (painDETECT)RA vs PsA · RA significantly lower | P = 0.002 |
Association with clinical measures (all questionnaires)
- Pain sensitivity and neuropathic like pain significantly associated with worse pain severity, disease activity, disability, quality of life and anxiety and depression measures
Neuropathic like pain as predictor of treatment outcome
- Studies inconsistent
Original publication
A systematic review and meta-analysis of questionnaires to screen for pain sensitisation and neuropathic like pain in inflammatory arthritis. Semin Arthritis Rheum. Published 26 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →