A single-center study of clinical features of pediatric Sjögren’s syndrome
Authors' conclusion
Patients with pediatric SS presented with a wide spectrum of clinical features, a low prevalence of reported symptoms of dry mouth and dry eyes, and various clinical manifestations with multi-system involvement.
Study context
- Population
- Children and adolescents with pediatric Sjögren's syndrome admitted to one hospital, September 2013 to September 2022females:males 49:5
- Participants
- 54 children
- Exposure
- Primary sjögren's syndrome (SS) vs secondary SS
- Primary SSn = 34
- Secondary SSn = 20
- Outcome
- Clinical features of pediatric SS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mean age at symptom onset (years)
- 9.9
- Mean age at diagnosis (years)
- 10.2
- Dry mouth reported
- 7 cases (13.0%)
- Dry eyes reported
- 5 cases (9.3%)
- Schirmer I test positive
- 9.3%
- Salivary gland function test positive
- 70.4%
- Salivary gland US positive
- 55.6%
- Anti-Ro/SSA positive
- 94.4%
- Anti-La/SSB positive
- 66.7%
- ANA positive
- 88.9%
- RF positive
- 59.3%
- IgG elevation
- 63.0%
- Treated with GC
- 88.9%
- Treated with HCQ
- 92.6%
Observational data: associations, not effects.
Further findings
Classification per Japanese pediatric SS guidance (2018)
- Definite SS
- 5
- Probable SS
- 35
- Possible SS
- 14
Original publication
A single-center study of clinical features of pediatric Sjögren’s syndrome. Pediatr Rheumatol Online J. Published 13 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →