Osteoporosis & bone health

A potential novel predictor of 1-year mortality in elderly hip fracture patients-albumin haemoglobin index

Osteoporos IntPublished Retrospective cohort study

Authors' conclusion

AHI is a potential novel predictor of 1-year mortality in elderly hip fracture patients, with prognostic performance comparable to RAR and superior to RDW.

Study context

Population
Patients aged ≥ 65 years who underwent hip fracture surgery, January 2020 to December 2021, managed in a Fracture Liaison Service
Participants
775 patients
Exposure
Preoperative albumin haemoglobin index (AHI) vs other preoperative blood parameters (RDW/albumin ratio (RAR), RDW) for predicting 1-year mortality
Outcome
1-year mortality
Follow-up
1 year
Methodological detailsROC analysis, Cox proportional hazards models
  • ROC analysis
  • Cox proportional hazards models

Main finding

As reported in the abstract

Prognostic performance for 1-year mortality (ROC)
GroupAUC
AHI0.75 (95% CI 0.71-0.80), p < 0.001
RAR0.77 (95% CI 0.73-0.82)
RDW0.72 (95% CI 0.67-0.77)

AUC

AHI0.75 (95% CI 0.71-0.80), p < 0.001
RAR0.77 (95% CI 0.73-0.82)
RDW0.72 (95% CI 0.67-0.77)
1-year mortality rate
16.6% (129/775)

Observational data: associations, not effects.

Further findings

Association with 1-year mortality (Cox models)

aHR (95% CI)P value
AHICutoff AHI < 33313.67 (2.44–5.51)P < 0.001
RARCutoff RAR > 0.4683.94 (2.62–5.90)
RDWCutoff RDW > 14.15%2.12 (1.43–3.14)

Mortality at 3 and 6 months (hazard models)

Consistent trends at 3 and 6 months for AHI < 3331, RAR > 0.468 and RDW > 14.15%

Original publication

A potential novel predictor of 1-year mortality in elderly hip fracture patients-albumin haemoglobin index. Osteoporos Int. Published 10 June 2025. doi:10.1007/s00198-025-07566-2

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