A comprehensive report of disease complications of juvenile idiopathic arthritis using a prospective cohort study
Authors' conclusion
Approximately one-third of patients in our cohort experienced at least one disease complication. Delayed initiation of biologic therapy was associated with higher complication rates
Study context
- Population
- Patients diagnosed with juvenile idiopathic arthritis (JIA) for more than one year evaluated at a rheumatology clinic, January 2023 to February 2024
- Participants
- 432 patients
- Outcome
- Disease complications (at least one disease complication)
Methodological detailsstandardized list of JIA disease complications created by consensus among rheumatologists, univariate analysis
- Standardized list of JIA disease complications created by consensus among rheumatologists
- Univariate analysis
Main finding
As reported in the abstract
At least one disease complication
Patients with at least one disease complication
146
33.8%
Observational data: associations, not effects.
Secondary outcomes
Joint complications
- Patients with joint complications
- 73 (16.9%)
Uveitis
- Patients with uveitis
- 57 (13.2%)
- Secondary ocular complications among patients with uveitis
- 14 (25%)
Growth failure and short stature
- Growth failure
- 4%
- Short stature
- 1%
Risk factors for complications
- Younger age at disease onset and longer time to initiation of biologic therapy associated with increased risk of complications
- Delayed initial rheumatology evaluation and delayed initiation of biologic therapy associated with progressively increasing risk of joint complications
Original publication
A comprehensive report of disease complications of juvenile idiopathic arthritis using a prospective cohort study. Pediatr Rheumatol Online J. Published 22 December 2025. doi:10.
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