3D analysis and grading of calcifications from ex vivo human meniscus
Authors' conclusion
3D μCT grading of meniscal calcifications is feasible.
Study context
- Population
- Human medial and lateral menisci from patients with medial compartment knee osteoarthritis (OA) undergoing total knee replacement and deceased donors without knee OA
- Participants
- 10 vs 10
- Comparison
- Menisci from knee replacement for medial compartment OA vs deceased donors without knee OA
- OAn = 10
- Healthy referencesn = 10reference
- Outcome
- Meniscal calcification volume (CVM) across μCT calcification grades (validation of new grading system)
Methodological detailsex vivo, μCT-based 3D analysis, histological comparison
- Ex vivo
- μCT-based 3D analysis
- Histological comparison
Main finding
As reported in the abstract
CVM per calcification grade
From grade 2, each grade: Calcification volumes (CVM) times higher than previous grade
20.3
95% CI 13.3–30.5
Original publication
3D analysis and grading of calcifications from ex vivo human meniscus. Osteoarthritis Cartilage. Published 7 November 2022. doi:10.
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