Across rheumatic diseases

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice

Ann Rheum DisPublished Points to consider

Recommendations

As issued by the authors

  1. Points to consider (PtC) 1-4: terminology, assay characteristics and reporting practices, to enable more consistent reporting and facilitate translation and collaborations

  2. PtC 5-11: clinical applications for diagnosis and outcome assessments, incl. disease activity, prognosis and prediction of treatment response

  3. Mean level of agreement generally high, mainly for PtC 1-4 and for clinical applications in SLE

  4. Research agenda: harmonisation of assay methodology and clinical validation

Original publication

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice. Ann Rheum Dis. Published 1 March 2023. doi:10.1136/ard-2022-223628

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