Sleep Disturbance and SARS–CoV‐2 Vaccinations in Patients With Chronic Inflammatory Disease
Authors' conclusion
Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased, and anxiety, fatigue, and sleep disturbance decreased.
Study context
- Population
- Individuals with chronic inflammatory disease (CID) from 2 sites undergoing SARS-CoV-2 vaccination (72% female; mean ± SD age 48.1 ± 15.5 years)
- Exposure
- PROs before vs after 2 mRNA SARS-CoV-2 vaccine doses, stratified by high vs low baseline anxiety
- Outcome
- Longitudinal change in PROs (PROMIS 29-item Health Profile, T scores)
- Follow-up
- 3 visits before and after 2 mRNA vaccine doses
Methodological detailslongitudinal, 2 sites, mixed-effects models adjusted for age, sex and study site
- Longitudinal
- 2 sites
- Mixed-effects models adjusted for age, sex and study site
Main finding
As reported in the abstract
PROMIS-29 T scores, overall cohort
- Sleep disturbance improved following both vaccine doses
- Anxiety decreased after the second dose
- Physical function worsened but did not meet the minimally important difference threshold
Observational data: associations, not effects.
Further findings
PROMIS-29 T scores, stratified by baseline anxiety
- Improvement in anxiety, fatigue and social participation greater in High anxiety
- Physical function worsened slightly in both groups
- Sleep disturbance improved significantly in High anxiety
Original publication
Sleep Disturbance and SARS–CoV‐2 Vaccinations in Patients With Chronic Inflammatory Disease. Arthritis Care Res (Hoboken). Published 13 February 2023. doi:10.
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