Spondyloarthritis & psoriatic arthritis
Window of opportunity in psoriatic arthritis: the earlier the better?
Authors' conclusion
In PsA, referral and diagnosis within 1 year is associated with better clinical outcomes, suggesting the presence of a window of opportunity.
Study context
- Population
- Newly diagnosed, DMARD-naïve psoriatic arthritis (PsA) patients in the Dutch southwest Early PsA cohoRt with ≥3 years of follow-up
- Participants
- 708 participants
- Exposure
- Short and intermediate vs long total diagnostic delay
- Short delayn = 136
- Intermediate delayn = 237
- Long delayn = 335reference
- Outcome
- MDA and DAPSA remission by total diagnostic delay
- Follow-up
- 3 years
Methodological detailsDutch southwest Early PsA cohoRt, ≥3 years of follow-up
- Dutch southwest Early PsA cohoRt
- ≥3 years of follow-up
Main finding
As reported in the abstract
Odds ratio (Minimal Disease Activity (MDA))
2.55
P = 0.003
Short delay
Odds ratio (DAPSA remission)
2.35
P = 0.004
Short delay
Observational data: associations, not effects.
Further findings
Patient and physician delay
- Patient delay
- 1.0 month
- Physician delay
- 4.5 months
Patient-reported outcomes · 3 years follow-up
- Numerical but non-significant differences between short and long delay
Characteristics associated with longer delay
- Female patients and those presenting with enthesitis, chronic back pain or normal C-reactive protein (CRP) had a longer delay
Original publication
Window of opportunity in psoriatic arthritis: the earlier the better? RMD Open. Published 27 February 2024. doi:10.
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