Spondyloarthritis & psoriatic arthritis
Sex Differences in the Effectiveness of First‐Line Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis: Results From the European Spondyloarthritis Research Collaboration Network
Authors' conclusion
Despite comparable disease characteristics at baseline, women with PsA have reduced treatment response and retention rates to their first TNFi
Study context
- Population
- Patients with psoriatic arthritis (PsA) starting their first tumor necrosis factor inhibitor (TNFi) across 13 European Spondyloarthritis Research Collaboration Network registries50% women
- Participants
- 7,679 patients
- Exposure
- Women vs men with PsA initiating first TNFi
- Outcome
- Low disease activity (LDA) by DAS28-CRP (<3.2)
- Follow-up
- 6 months
Methodological detailspooled registry data, 13 European registries pooled, logistic regression adjusted for age, country, csDMARD treatment and TNFi start year, Kaplan-Meier estimator
- Pooled registry data
- 13 European registries pooled
- Logistic regression adjusted for age, country, csDMARD treatment and TNFi start year
- Kaplan-Meier estimator
Main finding
As reported in the abstract
LDA (DAS28-CRP <3.2)
Women vs MenRelative risk (95% CI)
Unadjusted
0.82(0.80–0.84)
Adjusted
0.83(0.81–0.85)
Observational data: associations, not effects.
Further findings
| Outcome | Women | Men |
|---|---|---|
| TNFi retention rate, 6 / 12 / 24 months (n = 17,842) | 79%, 64%, and 50% | 88%, 77%, and 64% |
| Baseline DAS28-CRPMean | 4.4 (SD 1.2) | 4.2 (SD 1.2) |
TNFi retention rate, 6 / 12 / 24 months (n = 17,842)
- Women had significantly lower retention rates than men at all time points
Baseline DAS28-CRP
- Patient-reported outcome measures were worse in women
Original publication
Sex Differences in the Effectiveness of First‐Line Tumor Necrosis Factor Inhibitors in Psoriatic Arthritis: Results From the European Spondyloarthritis Research Collaboration Network. Arthritis Rheumatol. Published 25 February 2024. doi:10.
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