What role do socioeconomic and clinical factors play in disease activity states in rheumatoid arthritis? Data from a large UK early inflammatory arthritis audit
Authors' conclusion
Socioeconomic factors and deprivation were associated with pactiveRA, independent of clinical and disease characteristics.
Study context
- Population
- Adults with early RA in the National Early Inflammatory Arthritis Audit (UK), recruited May 2018 to October 2022
- Participants
- 682 vs 1,026
- Exposure
- Persistently active RA vs persistently low RA
- Persistently active rheumatoid arthritis (pactiveRA)n = 682
- plowRAn = 1,026reference
- Outcome
- Factors associated with pactiveRA (socioeconomic factors and comorbidities as exposures; age and gender a priori)
Methodological detailsnational audit, stepwise forward logistic regression
- National audit
- Stepwise forward logistic regression
Main finding
As reported in the abstract
Factors independently associated with pactiveRA (logistic regression)
- Depression, lung disease, gastric ulcers and baseline corticosteroid use also associated with pactiveRA
- p<0.05 for all
Observational data: associations, not effects.
Further findings
Women
| Outcome | pactiveRA | plowRA |
|---|---|---|
| Age, median · baseline | 58 (IQR 49–67) | 62 (IQR 52–72) |
Patient-reported outcomes and social patterning · baseline
- pactiveRA associated with worse baseline patient-reported outcomes and anxiety and depression screens
- Clear social patterning in pactiveRA, with age-by-gender interaction
Original publication
What role do socioeconomic and clinical factors play in disease activity states in rheumatoid arthritis? Data from a large UK early inflammatory arthritis audit. RMD Open. Published 14 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →