The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial
Authors' conclusion
Periodontal treatment is locally effective in patients with RA and impacts RA disease activity and anti-CCP2 antibody levels in patients with severe periodontitis.
Study context
- Population
- RA patients with moderate/severe periodontitis
- Participants
- 22 patients
- Comparison
- Full-mouth debridement in RA with severe vs moderate periodontitis
- Primary endpoint
- Change in DAS28 between V2 and V1
- Follow-up
- 2 months (V2)
Methodological detailsexploratory, delayed-start
- Exploratory
- Delayed-start
Primary result
As reported in the abstract
Change in DAS28 (ΔV2-V1) · 2 months
- Significant improvement in DAS28 after periodontal treatment in severe, but not moderate, periodontitis
- P = 0.042
Secondary outcomes
Change in DAS28 (ΔV3-V1) · 6 months
- Significant improvement in DAS28 in severe, but not moderate, periodontitis
- P = 0.001
Anti-CCP2 IgG levels · 6 months (V3)
- Significant reduction in severe, but not moderate, periodontitis
- P = 0.032
Baseline RA disease activity
- Significantly higher in severe vs moderate periodontitis, with significant positive correlations between several rheumatological and periodontal parameters
Original publication
The impact of periodontitis and periodontal treatment on rheumatoid arthritis outcomes: an exploratory clinical trial. Rheumatology (Oxford). Published 13 July 2024. doi:10.
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