Lupus & antiphospholipid syndrome
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies
Pooled result · Risk of SLE (pooled)Result — go to the resultOdds ratio 1.14 95% CI 0.86–1.52Authors' conclusion
This study suggests that vaccinations are not linked to an increased risk of SLE.
Study context
- Population
- Observational studies from PubMed, Cochrane Library and Embase, inception to September 3, 2023; follow-up 0.5 to 2 years
- Participants
- 45,067,349 participants17 studies
- Comparison
- Vaccination vs no vaccination
- Outcome
- Risk of systemic lupus erythematosus (SLE)
Methodological detailsNOS quality assessment, funnel plots and Egger's regression for publication bias
- NOS quality assessment
- Funnel plots and Egger's regression for publication bias
Pooled result
Risk of SLE (pooled)
Odds ratio
1.14
95% CI 0.86–1.52
P = 0.348
Vaccinationvs No vaccination
OR 1.14 (95% CI 0.86–1.52); P = 0.348
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Risk of SLE, HBV vaccination (subgroup)I2 = 63.3% | 2.11 (1.11–4.00) | P = 0.02 | |
| Risk of SLE, HPV vaccination (subgroup)I2 = 72.4% | 1.43 (0.88–2.31) | P = 0.148 | |
| Risk of SLE, influenza vaccination (subgroup)I2 = 0.0% | 0.96 (0.82–1.12) | P = 0.559 | |
| Risk of SLE, COVID-19 vaccine (subgroup)I2 = 91.3% | 0.44 (0.18–1.21) | P = 0.118 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Vaccination and the risk of systemic lupus erythematosus: a meta-analysis of observational studies. Arthritis Res Ther. Published 4 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →