Utilization of Biologic Disease‐Modifying Antirheumatic Therapy in Patients With Rheumatoid Arthritis and Recently Diagnosed Breast Cancer
Authors' conclusion
The utilization of tumor necrosis factor inhibitors and other bDMARDs in patients with RA and recent BC has not increased since 2008. Glucocorticoids utilization remained high. The largest predictor of bDMARD utilization was prior use before BC.
Study context
- Population
- Adults with rheumatoid arthritis (RA) and breast cancer (2008 onward)
- Participants
- 1,412 vs 1,439
- Exposure
- CDM vs SEER/TCR-Medicare
- CDMn = 1,412
- SEER/TCR-Medicaren = 1,439
- Outcome
- bDMARD utilization trends after breast cancer diagnosis
- Follow-up
- First three years after BC
Methodological detailsmultivariable logistic regression, three databases (CDM; SEER-Medicare; TCR-Medicare)
- Multivariable logistic regression
- Three databases (CDM; SEER-Medicare; TCR-Medicare)
Main finding
As reported in the abstract
bDMARD utilization · within first three years after diagnosis
Observational data: associations, not effects.
Further findings
bDMARD use in 3 months before BC diagnosis
Prior bDMARD use before breast cancer (BC) as predictor of bDMARD utilization
| OR (95% CI) | ||
|---|---|---|
| CDM: prior use | 27.15 (19.29–38.19) | |
| SEER/TCR: prior use | 18.98 (13.72–26.26) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| BC stage and bDMARD utilization (SEER/TCR-Medicare)Regional BCvs In situ or localized BC | 0.54 (0.36–0.82) | |
| BC stage and bDMARD utilization (SEER/TCR-Medicare)Distant BCvs In situ or localized BC | 0.31 (0.13–0.77) | |
| 0.10.31310Odds ratio (log scale) |
GC use
- About 70% of patients in the two cohorts received GC, with no significant time trend increases
Original publication
Utilization of Biologic Disease‐Modifying Antirheumatic Therapy in Patients With Rheumatoid Arthritis and Recently Diagnosed Breast Cancer. Arthritis Care Res (Hoboken). Published 6 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →