Utility of positron emission tomography as a new tool for muscle involvement in patients with idiopathic inflammatory myositis: a controlled study
Authors' conclusion
In patients with active IIM, median muscle FDG uptake with PET/CT was higher compared to non-IIM.
Study context
- Population
- Patients with active idiopathic inflammatory myositis (IIM) who had FDG PET/CT for malignancy screening, and matched non-IIM patients with malignancy160 IIM patients evaluated
- Participants
- 34 vs 14
- Comparison
- FDG PET/CT muscle uptake in active IIM vs age and sex matched non-IIM patients with malignancy
- IIMn = 34
- Non-IIMn = 14reference
- Outcome
- Diagnostic performance of positive FDG muscle uptake
Methodological detailscontrolled, age and sex matched controls
- Controlled
- Age and sex matched controls
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity |
|---|---|---|
| Muscle uptake vs liver | 37.1% | 100% |
| Muscle uptake vs mediastinum | 65.7% | 92.9% |
| Muscle uptake vs LTM | 91.4% | 7.1% |
Sensitivity
Muscle uptake vs liver37.1%
Muscle uptake vs mediastinum65.7%
Muscle uptake vs LTM91.4%
Specificity
Muscle uptake vs liver100%
Muscle uptake vs mediastinum92.9%
Muscle uptake vs LTM7.1%
Further findings
Factors associated with muscle PET/CT positivity (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Higher baseline CRP | 1.18 (1.03–1.36) | P = 0.017 | |
| Higher baseline LDH | 1.01 (1.001–1.017) | P = 0.029 | |
| 0.512Odds ratio (log scale) |
Original publication
Utility of positron emission tomography as a new tool for muscle involvement in patients with idiopathic inflammatory myositis: a controlled study. Clin Exp Rheumatol. Published 9 May 2023. doi:10.
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