Familial Co‐Aggregation of Idiopathic Inflammatory Myopathies and Cancer: A Swedish Population‐Based Study
Authors' conclusion
We found little evidence of shared familial susceptibility as a major pathologic mechanism contributing to the co-occurrence of IIM and cancer overall.
Study context
- Population
- Swedish national registers: first-degree relatives of patients with IIM and of matched individuals without IIM
- Participants
- 8,460 vs 41,127
- Exposure
- First-degree relatives of patients with IIM vs relatives of matched individuals without IIM
- First-degree relatives of patients with IIMn = 8,460
- Relatives of matched individuals without IIMn = 41,127reference
- Outcome
- Familial co-aggregation of IIM and cancer overall (adjusted OR)
Methodological detailsnational registers, matched, conditional logistic regression
- National registers
- Matched
- Conditional logistic regression
Main finding
As reported in the abstract
Familial co-aggregation of IIM and cancer overall
- No statistically significant familial associations between IIM and cancer overall
Observational data: associations, not effects.
Further findings
Familial co-aggregation of IIM and cancer in male relative pairs of patients with dermatomyositis
- Adjusted OR for familial association
- 1.39 [95% confidence interval (95% CI) 1.15-1.68]
- Remained statistically significant after controlling for multiple testing
- Consistent between kinships
Familial co-aggregation of IIM and cancer diagnosed before 50 years of age
- Only observed in offspring
Myeloid malignancies in male relative pairs (exploratory)
- Adjusted OR
- 2.27 [95% CI 1.43-3.60]
- Remained significant after controlling for multiple testing
Liver cancer in male relative pairs (exploratory)
- Adjusted OR
- 2.01 [95% CI 1.21-3.33]
- Remained significant after controlling for multiple testing
Original publication
Familial Co‐Aggregation of Idiopathic Inflammatory Myopathies and Cancer: A Swedish Population‐Based Study. Arthritis Rheumatol. Published 8 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →