Systemic sclerosis & Raynaud's
Usual interstitial pneumonia is the predominant histopathology in patients with systemic sclerosis receiving a lung transplant
Authors' conclusion
UIP is the predominant histopathology in patients with SSc receiving a lung transplant, with many patients concurrently having both NSIP and UIP or showing progression from NSIP to UIP over time before transplant.
Study context
- Population
- Patients receiving a lung transplant for SSc at a single centre, 2000–2021native lung transplant
- Participants
- 127 patients
- Outcome
- Histopathology of explanted lungs
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Usual interstitial pneumonia (UIP)
- 111 explants (87.4%)
- Nonspecific interstitial pneumonia (NSIP)
- 45 (35.4%)
- Organising pneumonia
- 11 explants (8.7%)
- Lymphocytic bronchitis
- 2 explants (1.6%)
- Both UIP and NSIP
- 37 explants (29.1%)
- Neither UIP nor NSIP
- 9 explants (7.1%)
Observational data: associations, not effects.
Further findings
Aspiration on histology
- Aspiration
- 49 (38.6%)
Prior surgical lung biopsy vs explant pathology (19 patients)
- Same primary pathology on biopsy and explant (2 NSIP, 9 UIP)
- 11
- Different pathology, all UIP on explant
- 8
Pulmonary hypertension and vasculopathy on explant
- Pulmonary hypertension and vasculopathy
- 101, 79.5%
Original publication
Usual interstitial pneumonia is the predominant histopathology in patients with systemic sclerosis receiving a lung transplant. Clin Exp Rheumatol. Published 17 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →