Using human genetics to understand the epidemiological association between obesity, serum urate, and gout
Authors' conclusion
Our comprehensive genome-wide cross-trait analysis demonstrates a shared genetic basis and pleiotropic loci, as well as a causal relationship between obesity, serum urate, and gout, highlighting an intrinsic link underlying these complex traits.
Study context
- Population
- Summary statistics from the largest GWAS for BMI, waist-to-hip ratio (WHR), WHR adjusted for BMI (WHRadjBMI), serum urate and gout (13,179 cases, 750,634 controls)GWAS summary statistics · largest GWAS for BMI 806,834 · WHR 697,734 · WHRadjBMI 694,649 · serum urate 288,649
- Comparison
- Obesity-related traits as exposures; gout and serum urate as outcomes
- Outcome
- Gout
Methodological detailsgenetic correlation, pleiotropic loci, Mendelian randomization, Transcriptome-wide association studies
- Genetic correlation
- Pleiotropic loci
- Mendelian randomization
- Transcriptome-wide association studies
Main finding
As reported in the abstract
Gout: genetic correlation and Mendelian randomization
- Genetic correlation BMI-gout (rg)
- 0.27, P = 6.62 × 10-7
- Genetic correlation WHR-gout (rg)
- 0.22, P = 6.26 × 10-7
- Genetic correlation WHRadjBMI-gout (rg)
- 0.07, P = 6.08 × 10-3
- Mendelian randomization BMI-gout OR
- 1.66 (1.45, 1.88) (95% CI)
- Mendelian randomization WHR-gout OR
- 1.57 (1.37, 1.81) (95% CI)
Secondary outcomes
Serum urate
- Similar pattern of correlation, pleiotropy and causality with even more pronounced magnitude and significance
Original publication
Using human genetics to understand the epidemiological association between obesity, serum urate, and gout. Rheumatology (Oxford). Published 3 February 2023. doi:10.
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