Vasculitis & polymyalgia rheumatica
Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy
Authors' conclusion
Our study confirms the utility of 18F-FDG PET-CT in patients presenting with suspected GCA and a negative TAB by demonstrating the presence of LV involvement across different subsets of the disease.
Study context
- Population
- Patients with suspected giant cell arteritis (GCA) and negative temporal artery biopsy (TAB) who underwent 18F-FDG PET-CT to confirm the diagnosis73 diagnosed with GCA
- Participants
- 127 patients
- Comparison
- 18F-FDG PET-CT vs clinical confirmation of GCA after ≥12 months follow-up
- 18F-FDG PET-CTn = 127
- Outcome
- Diagnostic performance of 18F-FDG PET-CT for LV involvement in GCA
Methodological detailsretrospective review of hospital databases, reference standard: clinical confirmation after ≥12 months follow-up
- Retrospective review of hospital databases
- Reference standard: clinical confirmation after ≥12 months follow-up
Performance
As reported in the abstract
Diagnostic performance of 18F-FDG PET-CT for LV involvement
| Test or model | Sensitivity | Specificity | Diagnostic accuracy | AUC |
|---|---|---|---|---|
| 18F-FDG PET-CT | 83.5% | 85.1% | 84% | 0.844 (95% CI: 0.752 to 0.936) |
18F-FDG PET-CT
Sensitivity83.5%
Specificity85.1%
Diagnostic accuracy84%
AUC0.844 (95% CI: 0.752 to 0.936)
- Positive PET-CT in patients with GCA
- 61/73 (83.5%)
- Positive PET-CT in patients without GCA (1 Erdheim-Chester disease, 3 IgG4-RD, 1 sarcoidosis, 3 isolated aortitis)
- 8/54 (14.8%)
Further findings
Sensitivity by GCA subset
- Sensitivity in occult systemic GCA
- 89%
- Sensitivity in extracranial LV-GCA
- 100%
Original publication
Usefulness of 18F-FDG PET-CT for assessing large-vessel involvement in patients with suspected giant cell arteritis and negative temporal artery biopsy. Arthritis Res Ther. Published 4 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →