Use of parenteral compared with oral glucocorticoids in early rheumatoid arthritis for chance of being off steroids and escalation of therapy at 1 year
Authors' conclusion
Patients receiving parenteral GC were half as likely to remain on GC at 12 months compared with those on oral GC. Rates of advanced therapy use were similar between groups.
Study context
- Population
- Adults with newly diagnosed early RA (symptoms <1 year), Canadian Early Arthritis Cohort, 2007–2023; median age 55 years
- Participants
- 2,222 adults
- Exposure
- Oral vs parenteral vs both oral and parenteral glucocorticoid (GC) vs no GC in the first 3 months
- No GCn = 1,661reference
- Oraln = 421
- Parenteraln = 121
- Bothn = 19
- Outcome
- Persistent GC use or escalation to advanced therapies
- Follow-up
- 12 months
Methodological detailsmultivariable logistic regression, adjusted
- Multivariable logistic regression, adjusted
Main finding
As reported in the abstract
GC use
Odds ratio
9.8
Oral
Odds ratio
4.1
Parenteral
Observational data: associations, not effects.
Further findings
Advanced therapy use · 12 months
Original publication
Use of parenteral compared with oral glucocorticoids in early rheumatoid arthritis for chance of being off steroids and escalation of therapy at 1 year. Ann Rheum Dis. Published 28 August 2026. doi:10.
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