Spondyloarthritis & psoriatic arthritis
Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy
Authors' conclusion
The advances in our understanding of pathogenesis, novel therapeutics, and nonpharmacologic interventions have revolutionized the management of SpA, but numerous questions around optimal management remain.
Study context
- Population
- Spondyloarthritis (SpA)
Methodological detailsnarrative review, Spondylitis Association of America Unmet Needs Conference IV
- Narrative review
- Spondylitis Association of America Unmet Needs Conference IV
Main finding
As reported in the abstract
- SpA pathogenesis incompletely understood; drivers include genetics, biomechanical stress and microbial factors
- Role of IL-23, IL-17 and TNF in the phases of inflammation remains unclear
- Future trials need better generalisability, robust subgroup analyses for distinct manifestations, focus on comparative efficacy, and clinician- and patient-relevant outcomes
- Mind-body interventions (tai chi, qigong, yoga, meditation) show encouraging evidence of benefit in SpA, particularly with pain
Original publication
Unmet Needs in Spondyloarthritis: Pathogenesis, Clinical Trial Design, and Nonpharmacologic Therapy. J Rheumatol. Published 24 October 2024. doi:10.
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