Uncovering risk factors for adverse events and infections in rheumatoid arthritis and rheumatoid arthritis with interstitial lung disease under treatment with biologics or targeted synthetic DMARDs: insights from the KOBIO Registry
Authors' conclusion
Patients with RA-ILD exhibited a higher rate of b/tsDMARDs withdrawal due to overall AEs and infections than those with RA without ILD. In the RA-ILD group, older age was identified as a risk factor for overall AEs, whereas a current smoking status was identified as a risk factor for infections.
Study context
- Population
- Adult patients with rheumatoid arthritis (RA) receiving b/tsDMARDs, Korean College of Rheumatology Biologics registry (KOBIO)
- Participants
- 169 vs 2,266
- Exposure
- RA-ILD vs all RA receiving b/tsDMARDs
- RA-ILDn = 169
- All RAn = 2,266reference
- Outcome
- Risk factors for overall AEs and infections in patients with RA-ILD receiving b/tsDMARDs
Methodological detailsmultivariable analysis
- Multivariable analysis
Main finding
As reported in the abstract
Older age, risk factor for overall adverse events (AEs): OR
3.01
p=0.014
Current smoking, the only risk factor for infections: OR
2.11
p=0.035
Observational data: associations, not effects.
Further findings
Withdrawal of b/tsDMARDs
Withdrawal of b/tsDMARDs
- Main reason for withdrawal in RA-ILD was AEs, infections the largest proportion of AEs
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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