Lupus & antiphospholipid syndrome
Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis
Authors' conclusion
Early-onset LN is characterized by elevated type I IFN activity and neutrophil-driven inflammation, reflecting a more aggressive phenotype.
Study context
- Population
- Patients with biopsy-confirmed lupus nephritis (LN)
- Participants
- 21 patients
- Comparison
- Early-onset vs late-onset LN
- Early-onsetn = 10
- Late-onsetn = 11reference
- Outcome
- Differential expression of type I IFN gene signatures in renal tissue
Methodological detailsRNA sequencing of renal biopsies, gene set enrichment analysis (GSEA)
- RNA sequencing of renal biopsies
- GSEA
Main finding
As reported in the abstract
- Genes differentiating the groups on hierarchical clustering (50 upregulated, 50 downregulated)
- 100
Further findings
Anti-dsDNA titres · significantly higher in early-onset
P = 0.024
Urinary N-acetyl-β-D-glucosaminidase · significantly higher in early-onset
P = 0.005
Original publication
Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis. Rheumatology (Oxford). Published 24 April 2025. doi:10.
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