Pediatric rheumatology

Treat-to-target strategies for the management of familial Mediterranean Fever in children

Pediatr Rheumatol Online JPublished Consensus statement

Methodological detailstreat-to-target recommendations, Systematic literature search, Delphi approach, online survey of paediatric rheumatologists in Germany, analysis of national AID-NET registry data
  • Treat-to-target recommendations
  • Systematic literature search, Delphi approach, online survey of paediatric rheumatologists in Germany, analysis of national AID-NET registry data

Recommendations

As issued by the authors

  1. 26 statements guiding Familial Mediterranean Fever (FMF) management with respect to diagnosis, treatment targets, treatment strategies and monitoring

  2. Multidimensional treatment targets incorporating objective and subjective reported outcome measures, stratifying patients into treatment paths: continue colchicine, persisting attacks / inflammation, colchicine intolerance, persisting arthritis, colchicine reduction and adjustment/reduction of biologics

  3. AID-NET registry: colchicine therapy successfully terminated in 61% of patients (27 out of 44) with heterozygous MEFV mutations

Original publication

Treat-to-target strategies for the management of familial Mediterranean Fever in children. Pediatr Rheumatol Online J. Published 26 September 2023. doi:10.1186/s12969-023-00875-y

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