Time-course of tophus resolution on Dual-energy CT and ultrasound after 24 months of a treat-to-target strategy: Results from GOUT-DECTUS study
Authors' conclusion
Complete tophus resolution is obtained at 24months of T2T in DECT but not in US, which provided a greater variability of volumetric assessments throughout follow-up.
Study context
- Population
- ULT-naïve patients with gout and ultrasound (US) tophi, during first 24 months of treat-to-target (T2T) urate-lowering therapy47/55 [85.5%] male
- Participants
- 55 patients
- Exposure
- Index tophus volume measured with US vs dual-energy CT (DECT)
- Outcome
- Change in absolute volume and relative change from baseline of index tophus volume measured with US and DECT, with correlation (Spearman ρ)
- Follow-up
- 6, 12 and 24 months
Methodological detailsmulticentre, 24-month, treat-to-target urate-lowering therapy
- Multicentre
- 24-month
- Treat-to-target urate-lowering therapy
Main finding
As reported in the abstract
Relative change from baseline in index tophus volume, median [IQR] · M6, M12, M24
Spearman ρ, month 6 (weak)
0.39
CI 0.01–0.74
US vs DECT
Spearman ρ, month 12 (moderate)
0.43
CI −0.14 to 0.82
US vs DECT
Spearman ρ, month 24 (moderate)
0.42
CI −0.01 to 0.73
US vs DECT
US
−96%
median · IQR −100–-72
DECT
−100%
median · IQR −100–-100
Observational data: associations, not effects.
Further findings
Absolute index tophus volume, baseline
Absolute index tophus volume, month 24
Original publication
Time-course of tophus resolution on Dual-energy CT and ultrasound after 24 months of a treat-to-target strategy: Results from GOUT-DECTUS study. Joint Bone Spine. Published 24 March 2025. doi:10.
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