The utility of miRNAs (miR-16), miR-146a and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring
Authors' conclusion
This study highlights the utility of miRNAs in JIA diagnosis, monitoring and prognosis and demonstrates the feasibility of using urine as a noninvasive source of miRNAs in children with non-systemic JIA.
Study context
- Population
- Juvenile idiopathic arthritis (JIA) patients and healthy controls; serial serum and urine samples
- Participants
- 31 vs 22
- Comparison
- JIA patients vs healthy controls
- JIAn = 31
- Healthy controls (HC)n = 22reference
- Outcome
- Diagnostic performance of serum and urine miR-16, miR-146a and miR-155 for distinguishing JIA from HC (AUC)
Methodological detailssingle-centre, serial serum and urine samples, RT-qPCR
- Single-centre
- Serial serum and urine samples
- RT-qPCR
Performance
As reported in the abstract
Distinguishing JIA from HC (ROC analysis)
- Serum miR-16, AUC 0.81 (95% CI 0.70-0.93), p < 0.001
- Serum miR-155, AUC 0.73 (95% CI 0.59-0.87), p = 0.005
- Urine miR-146a, AUC 0.68 (95% CI 0.53-0.82), p = 0.030
Further findings
High serum miR-146a as predictor of JIA remission (Kaplan-Meier)
| HR for JIA remission (95% CI) | P value | ||
|---|---|---|---|
| High serum miR-146a | 2.2 (0.7–6.9) | P = 0.040 | |
| 0.10.31310HR for JIA remission (log scale) |
Serum miR-16 and miR-155 change over follow-up · 12 months
- Increasing serum miR-16
- P = 0.021
- Decreasing serum miR-155
- P = 0.009
Urine miR-146a, JIA vs HC
- Lower miR-146a in urine of JIA patients
- P = 0.032
Original publication
The utility of miR-16, miR-146a and miR-155 in serum and urine for juvenile idiopathic arthritis diagnostics and monitoring. Pediatr Rheumatol Online J. Published 28 July 2025. doi:10.
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